Flunarizine 10mg + Propranolol HCL 40mg

Propranolol+ Flunarizine is indicated for the treatment of migraine. Migraine is a condition where there occurs severe throbbing pain or pulsating pain on one side of the head. One of the typical signs of migraine is severe and recurrent headache. The symptoms of migraine are nausea, vomiting, inability to speak, numbness or tingling, and sensitivity to light and noise.

Propranolol+ Flunarizine is a combination of 'Propranolol' (beta-blocker) and 'Flunarizine' (calcium channel blocker). Propranolol possesses anxiolytic (anxiety-decreasing), anti-arrhythmic (treats irregular heart rhythm), and antihypertensive (lowers blood pressure) effects. Propranolol acts by decreasing cerebral (brain) blood flow by acting directly on the brain's blood vessels. It also blocks the cortical spreading of depression and brain electrical activity responsible for pain and inflammation. It effectively cures and decreases the severity and frequency of migraine headaches. Flunarizine is a calcium channel blocker. It enhances blood flow and causes relaxation of blood vessels in the brain, thus stopping headaches due to migraine. It is also used to manage vertigo (spinning sensation).

Medical Benefits:-

Propranolol+ Flunarizine is indicated for the treatment of migraine. It is a combination of 'Propranolol' and 'Flunarizine'. Propranolol is a beta-blocker and possesses anxiolytic (anxiety-reducing), anti-arrhythmic, and antihypertensive actions. It reduces cerebral (brain) blood flow and cortical spreading depression, and electrical brain activity inducing pain and inflammation. It decreases the frequency and intensity of migraine headaches. Flunarizine is a channel blocker that enhances blood flow and widens blood vessels in the brain, thus preventing headaches due to migraine.

How Does Propranolol+ Flunarizine Medicine Work?

Propranolol + Flunarizine combines two drugs: Propranolol and Flunarizine, which is a preventative against migraine. Propranolol belongs to the class of beta blockers and Flunarizine belongs to the class of calcium channel blockers. They stabilize the hyperactive nerve cells and raise the threshold for activation of migraine. They also block cortical spreading depression (CSD- electrical waves that travel along the brain and bring about pain and inflammation).

Side Effects:-

• Weight gain
• Slow heart rate
• Tiredness
• Depression
• Drowsiness
• Abnormal dreams
• Cold extremities 

Precautions:-

• You are prescribed Propranolol + Flunarizine for the prevention of migraine headaches.
• Do not use it for the acute attack of migraine.
• It must be consumed at night time before retiring to bed.
• It can make you drowsy. Do not drive or operate machinery until you are sure how Propranolol + Flunarizine will affect you.
• Continue to take it daily consistently, even in the absence of symptoms.
• Pregnant and Breastfeeding women should take this medicine after asking your healthcare expert.
• Ask your medical history to your healthcare professional before taking this medicine.

Frequently Asked Questions(FAQ):-

Q. Can I take Propranolol+ Flunarizine for an acute/sudden attack of migraine?

Propranolol+ Flunarizine is not effective in a sudden attack of migraine. It is beneficial in the prevention of recurring episodes of migraine headaches. Inform your doctor if you experience sudden attacks so that they can prescribe other appropriate drugs.

Q. Are there any certain contraindications while taking Propranolol+ Flunarizine?

Propranolol+ Flunarizine is not recommended for asthma, bradycardia, arrhythmias, AV (Atrioventricular) block or sick sinus syndrome, depression, and Parkinson's disease. Please talk to your doctor before initiating Propranolol+ Flunarizine if you have a medical history.

Q. Can I discontinue Propranolol+Flunarizine when my symptoms are better?

Propranolol+ Flunarizine is administered as a prophylactic for the prevention of migraine headaches. Do not discontinue taking this medication until directed by your physician because it might make your migraine attacks recur. This medication includes propranolol and an abrupt withdrawal of propranolol can result in sweating, tremors, irregular or rapid heartbeat, deterioration of underlying angina, or heart attack. You should take Propranolol+ Flunarizine precisely as instructed by your physician.